Representative species-specific compounds across activity groups
| Cluster No. (Cluster Name) | Compound | hPXR Potencya | CYP3A4 Induction Potencya | rPXR Potencya |
|---|---|---|---|---|
| μM | ||||
| 1 (Phenothiazines) | Tropanyl 3,5-dimethylbenzoate | 3.5 | 15.8 | Inactive |
| 1 (Thioxanthenes) | Thiothixene hydrochloride | 12.6 | 7.1 | Inactive |
| 1 (Benztropines) | t-Butylhydroquinone | 12.6 | 2.0 | Inactive |
| 5 (Corticosteroids) | Carminomycin | Inactive | Inactive | 2.8 |
| 5 (Corticosteroids) | Dexamethasone acetate | Inactive | Inactive | 4.5 |
| 5 (Corticosteroids) | Fluorometholone | Inactive | Inactive | 0.4 |
↵a Taken from the primary qHTS screen.