Estimated PBPK model parameters
| Parameter | Value |
|---|---|
| ka | 0.409 |
| Ke | 0.0160 |
| Vmax | 0.0287 |
| Km | 0.050 |
| KADI | 1.61 |
| KADR | 2.05 |
| KBRA | 0.055 |
| KINT | 12.2 |
| KLIV | 7.54 |
| KLUN | 1.78 |
| KMUS | 2.08 |
| KRET | 4.01 |
| KSPL | 2.72 |
| KVIT | 0.012 |
| PAVIT | 0.0036 |
| KRES | 4.8 |
| PARES | 0.0048 |
| IIV ka | 31.2% |
| IIV ke | 6.4% |
| IIV Vmax | 40.6% |
| Residual error | 35.6% |