TABLE 3

Stability of acyl glucuronides of muraglitazar and peliglitazar in buffer and human plasma incubations at 50 μg/ml and 37°C

The buffer was 50 mM sodium phosphate, pH 7.4. Plasma samples were buffered with 50 mM phosphate, pH 7.4.

Compounds	Products	Buffer	Human Plasma
Disappearance of glucuronide (t_1/2, h)^{^a}
Muraglitazar AG	N.A.	1.23	0.33
Peliglitazar AG	N.A.	10.1	2.3
Aglycon formation rates [μg/(ml · h)]^{^b}
Muraglitazar AG	Muraglitazar	3.5	16.7
Peliglitazar AG	Peliglitazar	0.5	5.9

N.A., not applicable.
↵a t_1/2 was calculated from initial rates of glucuronide disappearance (t_1/2 = 0.693/slope).
↵b The value was the average of formation rates within the linear ranges (<3 h).