Kinetic parameters for LK-980 (1 μM) metabolism by primary human hepatocytes
HH-089, HH-129, and HH-114 were independent liver donors.
| Parameter | HH-089 | HH-114 | HH-129 |
|---|---|---|---|
| t1/2 (h) | >6.0 | 4.32 | >6.0 |
| Clint (ml/h · kg) | <183 | 254.5 | <183 |
| ClH (ml/h · kg) | <143 | 182.9 | <143 |
| E (extraction ratio) | <0.220 | 0.281 | <0.220 |