TABLE 2

Effects of NR1I2 genotypes on the rifampin-mediated metabolic induction of bupropion hydroxylation

	TGT Noncarrier (n = 22)	TGT Carrier (n = 13)	p^{^a}	−25385CC (n = 17)	−25385CT (n = 17)	−25385TT (n = 1)	p^{^b}
AUC_bup (ng · h/ml)
Basal	1274 ± 324	1194 ± 315	0.585	1260 ± 350	1247 ± 294	929	0.5525
Induced	435 ± 196	406 ± 176	0.785	418.2 ± 212.5	432.6 ± 168.1	370	0.8505
%difference^{^c}	−66.7 ± 10.4^*	−65.1 ± 15.8^*	0.960	−67.8 ± 11.2^*	−64.8 ± 14.1^*	−60.2	0.607
AUC_hyd (ng · h/ml)
Basal	9343 ± 3118	11,558 ± 4568	0.204	9290 ± 3276	10,695 ± 4112	16,053	0.231
Induced	9003 ± 2435	8541 ± 3304	0.489	8840 ± 2413	8837 ± 3202	8577	0.941
%difference	0.43 ± 23.3	−24.8 ± 11.8^*	<0.001	−0.78 ± 20.2	−14.8 ± 23.2^*	−46.6	0.017
AUC_hyd/AUC_bup
Basal	7.7 ± 3.1	10.3 ± 4.6	0.088	7.8 ± 3.4	9.0 ± 3.9	17.3	0.195
Induced	26.0 ± 19.2	27.3 ± 17.0	0.759	27.9 ± 21.5	25.3 ± 15.3	23.2	0.978
%difference	228 ± 95^*	169 ± 176^*	0.018	232 ± 98.3^*	182 ± 153^*	34.2	0.035

↵* p < 0.01, paired t test between the basal and induced states.
↵a Wilcoxon rank-sum test for the NR1I2 groups.
↵b Kruskal-Wallis test for −25385C>T groups; p < 0.05 indicated in bold.
↵c %difference represents the percent difference between basal and induced state, calculated as 100 × (induced − basal)/basal.