TABLE 3

Effects of the CYP2B6 genotype and NR1I2 genotypes on rifampin-mediated metabolic induction of bupropion hydroxylation

	CYP2B6*6 Noncarrier (n = 22)		P^{^a}	CYP2B6*6 Carrier (n = 13)		p^{^a}	p^{^b}
	TGT Noncarrier (n = 13)	TGT Carrier (n = 9)	P^{^a}	TGT Noncarrier (n = 9)	TGT Carrier (n = 4)	p^{^a}	p^{^b}
AUC_bup (ng · h/ml)
Basal	1307 ± 318	1187 ± 308	0.333	1227 ± 347	1209 ± 376	0.877
	1257 ± 312			1222 ± 340			0.539
Induced	437 ± 188	344 ± 161	0.243	430.6 ± 216.7	545.2 ± 132.3	0.165
	399 ± 180			466 ± 197			0.306
%difference^{^c}	67.2 ± 10.8	70.8 ± 12.2	0.512	65.8 ± 10.4	52.3 ± 16.8	0.199
	68.7 ± 11.3			61.7 ± 13.7			0.649
AUC_hyd (ng · h/ml)
Basal	10,465 ± 3112	12,796 ± 4007	0.324	7723 ± 2449	8776 ± 5073	0.940
	11,419 ± 3609			8047 ± 3269			0.004
Induced	9849 ± 1923	9756 ± 3050	0.845	7782 ± 2680	5808 ± 2117	0.199
	9811 ± 2378			7174 ± 2609			0.013
%difference	0.22 ± 28.0	−23.3 ± 10.5	0.021	0.76 ± 15.8	-28.1 ± 15.6	0.011
	−9.39 ± 25.1			−8.13 ± 20.5			0.468
AUC_hyd/AUC_bup
Basal	8.6 ± 3.5	11.3 ± 3.8	0.066	6.5 ± 2.0	8.0 ± 6.2	0.758
	9.7 ± 3.8			6.9 ± 3.6			0.012
Induced	30.0 ± 23.5	34.1 ± 15.5	0.333	20.3 ± 8.9	11.9 ± 7.7	0.045
	31.7 ± 20.3			17.7 ± 9.2			0.012
%difference	228 ± 107	218 ± 192	0.262	212 ± 78	58.8 ± 41.9	0.006
	225 ± 143			164 ± 99.7			0.287

p < 0.05 is indicated in bold.
↵a Wilcoxon rank-sum test for the NR1I2 groups within each CYP2B6 genotype group.
↵b Wilcoxon rank-sum test for the CYP2B6 groups.
↵c %difference represents the percent difference between basal and induced state, calculated as 100 × (induced − basal)/basal.