TABLE 4 Substrate specificity of OATP1B1, OATP1B3, and OATP 2B1 in transfected cells
Uptake was measured at 1 and 10 μM at 37°C for 3 min in HEK293-transfected cells and wild-type cells. The values are presented as uptake ratios (transfected/wild type). The values represent the mean of 2 to 3 replicates from a single experiment (designated with asterisks) or the mean of 2 to 3 experiments each run in duplicate or triplicate. Values in parentheses for OATP1B3 represent the uptake ratios in cells pretreated with sodium butyrate.