Enzyme kinetic parameters of exemestane metabolite formation in three human liver samples
| HLMs | 17-Hydroexemestane | 6-Hydroxymethylexemestane | ||||
|---|---|---|---|---|---|---|
| Km app | Vmax app | Clint app | Km app | Vmax app | Clint app | |
| μM | pmol/mg × min | Vmax/Km | μM | pmol/mg × min | Vmax/Km | |
| HLM (452183) | 14.51 | 176.24 | 12.15 | 40.41 | 739.04 | 18.3 |
| HLM (452165) | 15.65 | 274.51 | 17.54 | 31.50 | 999.29 | 31.72 |
| HLM (452172) | 10.92 | 216.38 | 19.81 | 39.34 | 605.13 | 15.4 |
| Mean | 13.7 | 222.4 | 16.5 | 37.1 | 781.15 | 21.80 |
Km app, apparent affinity; Vmax app, apparent maximum reaction velocity; Clint app, apparent intrinsic clearance.