TABLE 2

Correlation of mRNA expression levels between immunomodulators/transcription factors and P450 isoforms (n = 20)

Correlation between mRNA expression of P450 isoforms and transcription factors (or inflammatory markers) was determined by the Spearman rank analysis expressed as the corresponding correlation coefficient (r).

	Cyp1a2	Cyp2a5	Cyp2b10	Cyp2c37	Cyp2d22	Cyp2e1	Cyp3a11	Cyp3a41
Immunomodulator
IL-1β
r	0.048	0.077	−0.220	0.143	0.178	0.147	0.071	0.068
p value	0.842	0.746	0.351	0.548	0.453	0.537	0.766	0.776
IL-2
r	0.149	0.039	−0.052	0.013	0.025	−0.032	−0.049	0.167
p value	0.544	0.875	0.834	0.958	0.918	0.898	0.841	0.494
IL-4
r	0.389	0.214	0.037	0.448	0.578	0.539	0.516	−0.082
p value	0.090	0.365	0.878	0.048	0.008	0.014	0.020	0.731
IL-6
r	−0.158	0.095	−0.547	−0.076	0.048	0.191	−0.103	0.383
p value	0.506	0.692	0.013	0.749	0.842	0.420	0.665	0.095
IL-10
r	−0.289	−0.115	−0.539	−0.218	−0.104	0.014	−0.325	0.422
p value	0.216	0.629	0.014	0.355	0.662	0.955	0.162	0.064
IFN-γ
r	−0.040	−0.018	−0.310	−0.034	0.091	0.113	−0.187	0.074
p value	0.868	0.940	0.183	0.886	0.703	0.634	0.430	0.758
TNFα
r	−0.312	0.078	−0.535	−0.011	0.019	0.200	−0.166	0.213
p value	0.181	0.744	0.015	0.962	0.935	0.399	0.485	0.366
Transcription factor
PXR
r	0.370	0.587	0.278	0.382	0.333	0.361	0.551	−0.026
p value	0.109	0.007	0.235	0.097	0.152	0.118	0.012	0.913
CAR
r	0.385	0.171	−0.115	0.214	0.472	0.477	0.358	−0.121
p value	0.094	0.471	0.628	0.365	0.036	0.033	0.121	0.611
PPARα
r	0.475	0.457	−0.421	0.499	0.773	0.827	0.494	0.063
p value	0.034	0.043	0.065	0.025	<0.0001^*	<0.0001^*	0.027	0.793
ERα
r	−0.060	0.097	−0.170	0.544	0.466	0.624	0.589	−0.214
p value	0.803	0.686	0.473	0.013	0.038	0.003	0.006	0.365
AhR
r	0.521	0.355	0.268	0.256	0.332	0.226	0.210	0.292
p value	0.019	0.125	0.254	0.277	0.153	0.339	0.374	0.212

↵* p < 0.0005 after Bonferroni correction.