Accuracy in classification of midazolam DDIs (AUC ratio <2) based on predictions obtained using the dynamic model
All studies were reported as successfully predicted when assessed via the traditional two-fold measure approach.
| Inhibitor | Actual AUC Ratio and DDI Classification | Correct Classification of Predicted DDI Using Dynamic Model | |
|---|---|---|---|
| Atomoxetine | 1.0 | NI | ✓ |
| Atorvastatin | 1.4 | W | × (NI) |
| Chlorzoxazone | 1.7 | W | × (NI) |
| Cimetidine | 1.4 | W | × (NI) |
| Cimetidine | 1.4 | W | × (NI) |
| Cimetidine | 1.5 | W | × (NI) |
| Fluconazole | 1.9 | W | ✓ |
| Flumazenil | 0.97 | I | × (NI) |
| Fluvoxamine | 1.7 | W | × (NI) |
| Gatifloxacin | 1.1 | NI | ✓ |
| Parecoxib | 1.1 | NI | × (I) |
| Ranitidine | 1.2 | NI | ✓ |
| Ranitidine | 1.3 | W | × (NI) |
| Ranitidine | 1.7 | W | × (NI) |
| Azithromycin | 1.3 | W | ✓ |
| Carbamazepine | 0.04 | I | ✓ |
| Rifampin | 0.05 | I | ✓ |
| Nitrendipine | 0.93 | I | × (NI) |
| Simvastatin | 1.1 | NI | ✓ |
| Terbinafine | 0.76 | I | × (NI) |
| Valdecoxib | 1.1 | NI | ✓ |
| Fluoxetine | 0.84 | I | × (W) |
| Fluvoxamine | 1.39 | W | × (NI) |
I, NI, and W represent induction, no interaction, and weak inhibition interactions, respectively; ✓ represents the correct classification predicted; and × represents incorrect prediction, with the incorrect classification in parenthesis.