Turnover numbers of 12-HHT from metabolism of PGH2 by CYP1A1, 1A2, 1B1, 3A4, and 2S1
Turnovers are expressed as nanomoles of 12-HHT formed per nanomole of P450 per minute. Data are presented as means ± S.D. (n = 3).
| P450s | Turnover of 12-HHT from PGH2 |
|---|---|
| min−1 | |
| CYP1A1 | 2.25 ± 0.15 |
| CYP1A2 | 1.56 ± 0.02 |
| CYP1B1 | 2.46 ± 0.15 |
| CYP3A4 | 2.40 ± 0.15 |
| CYP2S1 | 1.59 ± 0.04 |