Cumulative excretion of radioactivity in urine and feces
Data are means ± S.D. from healthy male subjects treated with a single oral dose of 4.5 mg of [14C]fingolimod; n = 4.
| Excretion | |||
|---|---|---|---|
| Urine | Feces | Total excretion | |
| % dose | |||
| 0–72 h | 22.3 ± 5.3 | 5.4 ± 1.1 | 27.7 ± 5.3 |
| 0–240 h | 52.3 ± 6.3 | 9.9 ± 1.7 | 62.1 ± 7.6 |
| 288–312 h | 2.0 ± 0.5 | N.S. | |
| 456–480 h | 1.0 ± 0.4 | N.S. | |
| 792–816 h | 0.3 ± 0.2 | N.S. | |
| 0–816 h (estimated) | 78 ± 3 | 11 ± 2 | 89 ± 3 |
| 0–infinity (estimated by extrapolation) | 81 ± 3 | 11 ± 2 | 92 ± 2 |
N.S., not sampled.