TABLE 1

Tissue distribution of radioactivity in male rats after a single oral dose of [¹⁴C]apixaban at 5 mg/kg

Tissue	Apixaban
Tissue	0.5 h	1 h	4 h	8 h	24 h	72 h
	μg Eq/g
Adrenal gland	0.59	1.20	0.76	0.17	N.S.	N.S.
Blood	0.42	1.18	0.60	0.08	N.S.	N.S.
Bone marrow	0.26	0.57	0.32	0.07	N.S.	N.S.
Brain	0.05	BLQ	BLQ	BLQ	BLQ	BLQ
Brown fat	0.46	0.94	0.53	0.07	N.S.	N.S.
Harderian gland	0.21	0.69	0.42	0.12	N.D.	N.D.
Heart	0.33	0.70	0.45	0.08	N.D.	N.D.
Kidney (cortex)	0.81	1.72	1.36	0.88	BLQ	N.D.
Liver	0.81	1.72	1.36	0.39	BLQ	N.D.
Lung	0.57	0.70	0.64	0.14	BLQ	N.D.
Muscle	0.20	0.43	0.27	0.06	BLQ	N.D.
Pancreas	0.47	0.62	0.55	0.12	BLQ	N.D.
Pituitary gland	0.26	0.59	0.37	0.07	N.D.	N.D.
Salivary gland	0.30	0.72	0.54	0.13	BLQ	N.D.
Spleen	0.18	0.32	0.28	0.09	N.D.	N.D.
Thymus	0.16	0.46	0.23	0.06	N.D.	N.D.

N.S., not sampled because not visualized on autoradiograph, considered as BLQ; N.D., not detectable; BLQ, below limit of quantitation (0.037 μg Eq/g tissue).