Tissue distribution of radioactivity in female rats after a single oral dose of [14C]apixaban at 5 mg/kg
| Tissue | Apixaban | ||||||
|---|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 4 h | 8 h | 24 h | 72 h | ||
| μg Eq/g | |||||||
| Adrenal gland | 0.56 | 1.10 | 0.90 | 0.30 | N.D. | N.D. | |
| Blood | 0.40 | 0.88 | 0.35 | 0.17 | N.D. | N.D. | |
| Bone marrow | 0.29 | 0.41 | 0.26 | 0.15 | N.D. | N.D. | |
| Brain | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | |
| Brown fat | 0.48 | 0.77 | 0.61 | 0.17 | N.D. | N.D. | |
| Harderian gland | 0.40 | 0.64 | 1.12 | 0.22 | N.D. | N.D. | |
| Heart | 0.37 | 0.54 | 0.51 | 0.11 | N.D. | N.D. | |
| Kidney (cortex) | 0.82 | 1.36 | 1.21 | 0.42 | N.D. | N.D. | |
| Liver | 267 | 4.31 | 3.98 | 1.12 | BLQ | N.D. | |
| Lung | 0.43 | 0.883 | 0.51 | 0.20 | N.S. | N.S. | |
| Muscle | 0.23 | 0.27 | 0.29 | 0.08 | N.D. | N.D. | |
| Pancreas | 0.43 | 0.62 | 0.55 | 0.19 | N.D. | N.S. | |
| Pituitary | 0.43 | 0.42 | 0.48 | 0.22 | N.D. | N.D. | |
| Salivary gland | 0.28 | 0.55 | 0.44 | 0.13 | N.D. | N.D. | |
| Spleen | 0.29 | 0.35 | 0.45 | 0.13 | N.D. | N.D. | |
| Thymus | 0.20 | 0.27 | 0.30 | 0.09 | N.D. | N.D. | |
N.S., not sampled because not visualized on autoradiograph, considered as BLQ; N.D., not detectable; BLQ, below limit of quantitation (0.037 μg Eq/g tissue).