Tissue distribution of radioactivity in pregnant rats after a single oral dose of [14C]apixaban at 5 mg/kg
| Tissue | Apixaban | |||||
|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 4 h | 8 h | 24 h | 48 | |
| μg Eq/g | ||||||
| Adrenal gland | 1.49 | 1.90 | 2.30 | 0.18 | N.S. | N.S. |
| Blood | 1.43 | 1.44 | 1.30 | 0.09 | N.D. | N.D. |
| Bone marrow | 0.50 | 0.33 | 0.46 | 0.06 | N.D. | N.D. |
| Brain | 0.05 | 0.06 | BLQ | BLQ | N.D. | N.D. |
| Brown fat | 1.08 | 0.95 | 0.87 | 0.06 | N.D. | N.D. |
| Harderian gland | 1.00 | 1.09 | 1.1 | 0.19 | N.D. | N.D. |
| Heart | 0.68 | 0.93 | 0.83 | 0.06 | N.D. | N.D. |
| Kidney (cortex) | 2.11 | 2.03 | 1.93 | 0.21 | 0.05 | N.D. |
| Liver | 6.77 | 7.38 | 6.13 | 0.65 | 0.12 | N.D. |
| Lung | 1.65 | 1.56 | 1.33 | 0.15 | BLQ | N.D. |
| Muscle | 0.37 | 0.46 | 0.50 | 0.05 | N.D. | N.D. |
| Pancreas | 0.89 | 0.75 | 0.99 | 0.09 | N.D. | N.D. |
| Pituitary | 0.72 | 0.93 | 0.75 | 0.19 | N.S. | N.S. |
| Salivary gland | 0.73 | 0.95 | 1.03 | 0.08 | N.D. | N.D. |
| Spleen | 0.46 | 0.51 | 0.47 | 0.05 | BLQ | N.D. |
| Thymus | 0.38 | 0.58 | 0.54 | 0.05 | N.D. | N.D. |
| Amnion | 1.45 | 2.12 | 11.24 | 2.12 | 3.52 | N.S. |
| Placenta | 1.02 | 0.74 | 1.06 | 0.10 | BLQ | N.D. |
| Fetal blood | 0.27 | 0.31 | 0.51 | 0.07 | N.D. | N.D. |
| Fetal brain | BLQ | 0.05 | 0.06 | BLQ | N.D. | N.D. |
| Fetal kidney | 0.24 | 0.20 | 0.46 | N.S. | N.S. | N.S. |
| Fetal liver | 0.16 | 0.22 | 0.32 | 0.06 | N.S. | N.S. |
N.S., not sampled because not visualized on autoradiograph, considered as BLQ; N.D., not detectable; BLQ, below limit of quantitation (0.037 μg Eq/g tissue).