Summary of pharmacokinetic parameters of total radioactivity in human plasma after a single oral dose of 10 mg of [14C]peliglitazar
Data are presented as means ± S.D. All P > 0.05, t test, group 1 versus group 2.
| Group | Cmax | AUC(0–12 h) | Tmax | t1/2 |
|---|---|---|---|---|
| ng/ml | ng · h/ml | h | h | |
| All subjects (n = 8) | 251 ± 47 | 958 ± 339 | 1.1 ± 0.4 | 3.5 ± 1.1 |
| Group 1 (n = 6) | 257 ± 56 | 1035 ± 328 | 1.1 ± 0.5 | 3.6 ± 1.1 |
| Group 2 (n = 4) | 242 ± 35 | 844 ± 371 | 1.0 ± 0.4 | 3.3 ± 1.2 |