Concentration of radioactivity in female rat plasma and tissues after single (day 1) and repeat (day 20) oral administration of [14C]casopitant and at 7 (day 27) and 20 (day 40) days after completion of repeat dosing at 60 mg/kg/day
Results are reported as means ± SD. Data are presented to three significant figures or to a maximum of three decimal places and are computer-generated and rounded appropriately.
| Sample | Time Point | Day 1 (n = 12) | Day 20 (n = 12) | Day 27 (Recovery Phase) (n = 6) | Day 40 (Recovery Phase) (n = 6) |
|---|---|---|---|---|---|
| h | μg Eq casopitant free base/g | ||||
| Plasma | 2 | 6.06 ± 1.26 | 18.5 ± 2.6 | ||
| 24 | 5.54 ± 1.17 | 12.4 ± 2.1 | 1.92 ± 0.42 | 0.246 ± 0.018 | |
| Blood | 24 | 5.60 ± 0.97 | 14.5 ± 4.7 | 7.67 ± 1.78 | 3.63 ± 0.14 |
| Myocardium | 24 | 34.6 ± 6.5 | 79.6 ± 16.2 | 32.9 ± 6.3 | 26.7 ± 6.0 |
| Lungs | 24 | 135 ± 55 | 405 ± 109 | 136 ± 6.0 | 96.8 ± 14.2 |
| Kidneys | 24 | 59.1 ± 6.8 | 256 ± 91.6 | 64.6 ± 15.7 | 39.2 ± 8.4 |
| Liver | 24 | 121 ± 14.5 | 545 ± 92.8 | 240 ± 52.2 | 90.4 ± 31.7 |
| Skeletal muscle | 24 | 18.3 ± 3.1 | 28.1 ± 5.4 | 10.7 ± 1.5 | 7.74 ± 0.76 |