TABLE 2

Concentration of radioactivity in male dog plasma and tissues after single (day 1) and repeat (day 14) oral administration of [14C]casopitant and at 20 (day 34) days after completion of repeat dosing at 40 mg/kg/day

Results are reported as mean (n = 2 unless stated otherwise) ± S.D. if applicable. Data are presented to three significant figures and are computer-generated and rounded appropriately.

SampleTime PointDay 1Day 14Day 34 (Recovery Phase)
hμg Eq casopitant free base/g
Plasma220.869.5 ± 4.1a
249.6849.2 ± 5.0a11.6
Blood211.347.4 ± 2.5a
249.4035.3 ± 3.4a9.95
Myocardium24N.D.24396.2
Lungs24N.D.905345
Kidneys24N.D.308102
Liver24N.D.1050612
Skeletal muscle24N.D.99.221.3
  • N.D., not determined.

  • a n = 4.