Parameter | Toxicokinetic Parameters | ||||||
---|---|---|---|---|---|---|---|
Casopitant | M12 | M13 | M31 | M76a | M134 | M200a | |
AUC0–t (ng · h/ml) | 53,599 (27,722–84,585) | 21,248 (13,953–29,634) | 61,603 (34,619–96,130) | 3040 (2189–4131) | 1803 | 22858 (21,102–24,695) | 1442 |
N.A. | N.A. | ||||||
2289 | N.A. | ||||||
Cmax (ng/ml) | 7167 (4800–10,193) | 1013 (763–1336) | 4357 (3331–5810) | 189 (160–244) | 82.0 | 1044 (912–1190) | 65.5 |
N.A. | N.A. | ||||||
102 | N.A. | ||||||
Tmax (h) | 1.00 (1.00–1.00) | 8.00 (6.00–24.0) | 4.00 (2.00–4.00) | 1.00 (0.50–2.00) | 8.00 | 24.0 (2.00–24.0) | 24.0 |
N.A. | N.A. | ||||||
2.00 | N.A. |
N.A., toxicokinetic parameters not available because plasma levels were below the limit of quantification (50 ng/ml) at all time-points considered.
↵a Mean was not calculated where n <3; therefore, individual toxicokinetic parameters are reported.