TABLE 5

Toxicokinetic parameters for casopitant, M12, M13, M31, M76, M134, and M200 after repeat oral administration of casopitant mesylate to male beagle dogs at 40 mg/kg/day at 26 weeks

Results are reported as mean (range), where n = 3, for AUC and Cmax or median (range) for Tmax.

ParameterToxicokinetic Parameters
CasopitantM12M13M31M76aM134M200a
AUC0–t (ng · h/ml)53,599 (27,722–84,585)21,248 (13,953–29,634)61,603 (34,619–96,130)3040 (2189–4131)180322858 (21,102–24,695)1442
N.A.N.A.
2289N.A.
Cmax (ng/ml)7167 (4800–10,193)1013 (763–1336)4357 (3331–5810)189 (160–244)82.01044 (912–1190)65.5
N.A.N.A.
102N.A.
Tmax (h)1.00 (1.00–1.00)8.00 (6.00–24.0)4.00 (2.00–4.00)1.00 (0.50–2.00)8.0024.0 (2.00–24.0)24.0
N.A.N.A.
2.00N.A.
  • N.A., toxicokinetic parameters not available because plasma levels were below the limit of quantification (50 ng/ml) at all time-points considered.

  • a Mean was not calculated where n <3; therefore, individual toxicokinetic parameters are reported.