| | | % | | % |
Cli (l/h) | Intrinsic blood clearance in hepatocytes | 0.31 | 91 | N.E. | |
Km = Kme (mg/l) | Michaelis-Menten constant of metabolic process in liver and enterocyte | 72.0 | N.E. | 148 | N.E. |
k12 (h−1) | Intercompartmental rate constant | 2.80a | N.E. | 2.31a | N.E. |
k21 (h−1) | Intercompartmental rate constant | 1.14a | 37a | 0.63a | 71a |
Vc (l) | Volume of distribution in central compartment | 0.24a | 73a | 0.38a | 60a |
kB (l/mg · h) | Protein-binding rate constant | 1.12 × 10−6 | 40a | | |
kU (h−1) | Protein-unbinding rate constant | 0.20 | 78a | | |
QMA (mg) | Maximum binding capacity of the proteins for SQV | 21,700 | 51a | | |
kaIP (h−1) | Absorption rate constant for intraperitoneal administration | 1.09a | 166a | 0.38a | N.E. |
BIOIP | Fraction of amount absorbed by intraperitoneal route | 1a | N.E. | 1a | N.E. |
FR(G8) | Fraction of dose that precipitate after intraperitoneal administration in group 8 | 0.97a | N.E. | 0.87a | N.E. |
FR(G7) = (1 + FR(G8))/2 | Fraction of dose that precipitated after intraperitoneal administration in group 7 | 0.98a | | 0.93a | |
kD (G7) (h−1) | Dissolution rate constant for group 7 | 0.04a | | 0.04a | |
kD (G8) (h−1) | Dissolution rate constant for group 8 | 0.48a | N.E. | 4.46a | N.E. |
Ka1 (h−1) | Absorption rate constant for oral administration from intestinal compartment 1 | 0.24 | 56 | 0.24 | 1.5 |
kT (h−1) | Intestinal transit rate constant | 0.58 | 61 | 0.12 | 126 |
Qh (l/h) | Hepatic flow | 1.15b | 6.5b | 1.15b | 6.5b |
Vh (l) | Volume of distribution in hepatocyte compartment | 0.01b | | 0.01b | |
Ve (l) | Volume of distribution in enterocyte compartment | 0.006b | | 0.006b | |
Clie (l/h) | Intrinsic blood clearance due to metabolism in enterocytes | 4.35 | 92 | 2.35 | 113 |
Clise (l/h) | Intrinsic blood clearance of intestinal secretion | 2.83 × 10−6 | 6.9 | | |
Kme (mg/l) | Michaelis-Menten constant of enterocyte secretion process | 0.02 | | | |
Ka2 (h−1) | Absorption rate constant after oral administration from intestinal compartment 2 | 0.17 | 59 | | |
FKm (G9) | Factor that modified the Michaelis-Menten constant for group 9 | 5.16 | | 5.05 | |
FKm (G10) | Factor that modified the Michaelis-Menten constant for group 10 | 10.2 | | 38 | |
σ1 (CV %) | Residual variability; exponential component | 12.2 | | 24 | |
σ2 (mg/l) | Residual variability; additive error | 0.29 | | 0.23 | |