TABLE 7

Casopitant pharmacokinetics after a single oral dose at 100 mg: comparison of clinical results and SimCyp simulations

CasopitantCasopitant CmaxCasopitant AUC
Clinical MeanaPredicted MeanbClinical MeanaPredicted Meanb
ng/mlng · h/ml
100 mg457 (415–498)340 (140–650)2590 (2240–2930)4760 (2350–8610)

  • ↵a Exposure clinical data are given with the 90% confidence interval given in parentheses.

  • ↵b Predicted data are data generated by SimCyp, with the 90% confidence interval given in parentheses.