TABLE 5

Comparison of P450 phenotyping data using rhP450-ISEF extrapolation and HLM chemical inhibition for proprietary compounds

Compound	P450	rhP450 CL_int	HLM CL_int-ISEF Extrapolated	% Contribution
Compound	P450	rhP450 CL_int	HLM CL_int-ISEF Extrapolated	Calculated	Measured (HLM with Inhibitor)^{^a}
		μl per min/pmol	μl per min/mg
I	2D6	3.50	5.04	65	51
	2C19	0.434	1.52	19	25
	1A2	0.141	1.25	16	24
II	3A4	0.708	15.5	100	75
	1A2	N.D.	N.D.		12
	2C9	N.D.	N.D.		13
III	3A4	0.932	20.4	85	100^{^b}
	2C9	0.058	3.7	15	N.A.
IV	3A4	1.07	23.4	72	71
	2C9	0.08	5.10	16	29
	2C19	1.10	3.85	12	N.A.
V	3A4	0.770	16.8	96	94
	2C19	0.219	0.77	4	6
VI	3A4	2.02	44.2	100	100
VII	3A4	0.781	17.1	90	86
	2C8	0.045	1.52	8.1	N.A.
	2C19	0.078	0.27	1.4	14
VIII	3A4	1.064	23.3	94	81
	1A2	0.163	1.44	6	19
IX	3A4	1.412	30.9	79	67
	1A2	0.318	2.81	7.2	3.4
	2C19	0.547	1.91	4.9	8.8
	2C9	0.047	2.98	7.7	9.6
	2D6	0.193	0.28	0.7	11
X	3A4	0.912	19.4	77	80^{^c}
	1A2	0.256	2.26	8.9	14^{^c}
	2C8	0.091	3.08	12	4.5^{^c}
	2C19	0.157	0.55	2.2	1.7^{^c}