Accuracy of extrapolation of P450 contributions using ISEF determined by different methods and substrates
| Average Fold Error (rhP450-ISEF Extrapolated/Directly Measured in HLM) | |||
|---|---|---|---|
| CYP2C9 Contribution (n = 7 Compounds) | CYP2D6 Contribution (n = 7 Compounds) | CYP3A4 Contribution (n = 17 Compounds) | |
| ISEF determined using different methods | |||
| ISEF-CLint | 1.03 | 1.05 | 1.05 |
| VISEF | 1.15 | 1.10 | 1.17 |
| CLISEF | 1.96 | 1.03 | 1.16 |
| ISEF-CLint determined using different substrates | |||
| CYP2C9 | |||
| Diclofenac | 1.55 | ||
| S-Warfarin | 1.14 | ||
| Tolbutamide | 1.11 | ||
| CYP2D6 | |||
| Bufuralol | 1.19 | ||
| Dextromethorphan | 1.08 | ||
| CYP3A4 | |||
| Midazolam | 1.03 | ||
| Testosterone | 1.14 | ||
| Nifedipine | 1.24 | ||