Measured fu,brain (%) in TRANSIL, as discrete or as a cocktail (pooling four compounds in one sample)
| Drug Name | fu,brain (%) ± S.D. TRANSIL Discrete | fu,brain (%) ± S.D. TRANSIL Cocktail | Fold Change |
|---|---|---|---|
| GSK28 | 0.05 ± 0.01 | 0.05 ± 0.01 | 1.0 |
| GSK27 | 0.17 ± 0.01 | 0.14 ± 0.01 | 1.2 |
| GSK30 | 0.20 ± 0.01 | 0.22 ± 0.01 | 0.9 |
| GSK33 | 0.20 ± 0.01 | 0.15 ± 0.01 | 1.3 |
| GSK15 | 0.70 ± 0.05 | 0.49 ± 0.02 | 1.4 |
| GSK26 | 0.70 ± 0.05 | 0.60 ± 0.03 | 1.2 |
| Clozapine | 0.72 ± 0.02 | 0.92 ± 0.01 | 0.8 |
| Amitriptyline | 0.73 ± 0.02 | 0.71 ± 0.01 | 1.0 |
| Haloperidol | 1.4 ± 0.1 | 1.4 ± 0.2 | 1.0 |
| GSK22 | 2.0 ± 0.1 | 1.9 ± 0.1 | 1.1 |
| GSK24 | 2.00 ± 0.01 | 1.84 ± 0.03 | 1.1 |
| Propranolol | 2.0 ± 0.1 | 2.0 ± 0.1 | 1.0 |
| GSK18 | 2.3 ± 0.1 | 1.90 ± 0.02 | 1.2 |
| Midazolam | 4.1 ± 0.2 | 3.7 ± 0.2 | 1.1 |
| GSK19 | 4.2 ± 0.1 | 2.5 ± 0.1 | 1.7 |
| GSK25 | 4.2 ± 0.2 | 3.6 ± 0.2 | 1.2 |
| GSK17 | 6.0 ± 0.4 | 6.6 ± 0.4 | 0.9 |
| GSK29 | 6.2 ± 0.2 | 5.9 ± 0.5 | 1.1 |
| GSK21 | 7.0 ± 0.2 | 6.7 ± 0.3 | 1.0 |
| GSK16 | 9.8 ± 0.6 | 11.2 ± 0.6 | 0.9 |
| Carbamazepine | 13 ± 1 | 26 ± 5 | 0.5 |
| Bupivacaine | 17 ± 3 | 19 ± 4 | 0.9 |
| GSK23 | 17 ± 1 | 15 ± 1 | 1.1 |
| Buproprion | 17 ± 4 | 14 ± 4 | 1.2 |
| GSK20 | 24.2 ± 0.4 | 25 ± 4 | 0.9 |