TABLE 2

In vitro binding data of PF02341066 and PF04217903 across species

Data represent the mean of triplicate determination. f_{u,| plasma}, R_bp, and f_{u,| microsomes} were experimentally determined. f_{u,| blood} and f_{u,| hepatocytes} were calculated by the equations described under Materials and Methods.

Compound	Species	f_{u,\| plasma}	R_bp	f_{u,\| blood}	f_{u,\| microsomes}	f_{u,\| hepatocytes}
PF02341066	Rat	0.057	0.880	0.065	0.116	0.144
	Dog	0.043	0.850	0.051	0.091	0.113
	Monkey	0.072	1.37	0.053	0.103	0.129
	Human	0.093	1.01	0.092	0.122	0.151
PF04217903	Rat	0.197	0.980	0.201	0.808	0.843
	Dog	0.341	0.806	0.423	0.780	0.819
	Human	0.164	0.897	0.183	0.792	0.830