Drug | Blood Conc. | Corrected Brain Conc. | Brain/Blood Ratio | |||
---|---|---|---|---|---|---|
Young | Old | Young | Old | Young | Old | |
μM | ||||||
Donepezil | 0.13 ± 0.01 | 0.21 ± 0.11 | 0.57 ± 0.09 | 1.02 ± 0.23* | 4.4:1 ± 0.3 | 5.3:1 ± 1.8 |
Tacrine | 0.11 ± 0.03 | 0.19 ± 0.12 | 1.24 ± 0.30 | 1.72 ± 0.93 | 11.0:1 ± 1.2 | 9.5:1 ± 0.7 |
Galantamine | 0.42 ± 0.02 | 0.58 ± 0.21 | 0.73 ± 0.04 | 1.14 ± 0.39 | 1.7:1 ± 0.2 | 2.0:1 ± 0.0 |
↵* p < 0.05.