TABLE 1

Glucuronidation assay conditions for individual substrates (LC-MS analyses)

Concentrations of the different substrates in the glucuronidation assays and the concentrations of DMSO that were used for the samples that were analyzed by LC-MS (see text and results in Table 3). In subsequent HPLC and UPLC assays, the substrate concentrations were as indicated here, whereas the DMSO concentrations were either as indicated here or 1% for all compounds. In addition, alamethicin was included in the assays with HIM and HLM (see text and results in Table 4).