Substrates | U Caco-2 Cells | D Caco-2 Cells | HIM | HLM |
---|---|---|---|---|
peak areas per mg/h | ||||
1-Naphthol | 743 ± 40 | 1512 ± 55 | 446 ± 26 | 7367 ± 388 |
Diclofenac (G-1) | 0.85 ± 0.14 | 2.72 ± 0.12 | 244 ± 19 | 2213 ± 111 |
Diclofenac (G-2) | 0.80 ± 0.08 | 1.86 ± 0.11 | 219 ± 33 | 1804 ± 202 |
Epitestosterone | 0.56 ± 0.00 | 11.0 ± 0.3 | 323 ± 20 | 2779 ± 88 |
Estradiol (3-G) | 0.61 ± 0.08 | 2.58 ± 0.07 | 6550 ± 304 | 3867 ± 377 |
Estradiol (17-G) | 0.14 ± 0.00 | 1.14 ± 0.04 | 129 ± 10 | 404 ± 40 |
Ethinylestradiol | 0.42 ± 0.00 | 3.18 ± 0.22 | 883 ± 120 | 4346 ± 525 |
Indomethacin (G-1) | 0.28 ± 0.00 | 1.21 ± 0.04 | 269 ± 23 | 1496 ± 88 |
Indomethacin (G-2) | N.D. | 0.07 ± 0.00 | 45.8 ± 9.6 | 242 ± 31 |
Propofol | 2.78 ± 0.16 | 12.3 ± 0.3 | 1040 ± 4 | 1929 ± 151 |
R-Oxazepam | N.D. | N.D. | N.D. | 25.0 ± 0.0 |
S-Oxazepam | N.D. | 0.07 ± 0.00 | N.D. | 25.0 ± 0.0 |
R-Propranolol | 0.14 ± 0.00 | 0.39 ± 0.04 | 110 ± 4 | 1600 ± 102 |
S-Propranolol | 0.19 ± 0.08 | 0.39 ± 0.04 | 64.6 ± 3.6 | 1850 ± 70 |
Testosterone | 0.28 ± 0.00 | 7.40 ± 0.42 | 1492 ± 13 | 1283 ± 7 |
TFP | N.D. | N.D. | 115 ± 6 | 14,730 ± 737 |
AZT | N.D. | 0.81 ± 0.04 | 25.0 ± 0.0 | 271 ± 7 |
G, glucuronide; N.D., not detected.