Marker in Fig. 4 | Compound | pKa | Class | fup ± S.D. | |||
---|---|---|---|---|---|---|---|
Buffer 2, Normal Atmospheric Conditions; Postdialysis Plasma pH 7.22 | Buffer 3, 5% CO2; Postdialysis Plasma pH 7.40 | Buffer 4, 5% CO2; Postdialysis Plasma pH 7.63 | Buffer 1, Normal Atmospheric Conditions; Postdialysis Plasma pH 7.72 | ||||
A | Diazepam | 3.4 | Neutral | 0.019 ± 0.002 | 0.016 ± 0.003 | 0.019 ± 0.003 | 0.023 ± 0.001 |
B | Diclofenac | 4.0 | Acid | 0.003 ± 0.001 | 0.007 ± 0.000 | 0.005 ± 0.002 | 0.004 ± 0.002 |
C | Cinoxacin | 4.7 | Acid | 0.251 ± 0.104 | 0.214 ± 0.016 | 0.230 ± 0.039 | 0.266 ± 0.025 |
D | Warfarin | 4.9 | Acid | 0.009 ± 0.002 | 0.014 ± 0.003 | 0.013 ± 0.003 | 0.006 ± 0.002 |
E | Nicardipine | 7.2 | Base | 0.008 ± 0.002 | 0.005 ± 0.001 | 0.008 ± 0.002 | 0.003 ± 0.001 |
F | Mirtazapine | 7.3 | Base | 0.320 ± 0.025 | 0.286 ± 0.034 | 0.266 ± 0.058 | 0.160 ± 0.045 |
G | Buspirone | 7.3 | Base | 0.333 ± 0.022 | 0.277 ± 0.022 | 0.261 ± 0.039 | 0.214 ± 0.041 |
H | Clozapine | 7.5 | Base | 0.101 ± 0.012 | 0.081 ± 0.011 | 0.058 ± 0.011 | 0.042 ± 0.009 |
I | Diltiazem | 8.0 | Base | 0.417 ± 0.038 | 0.349 ± 0.015 | 0.350 ± 0.030 | 0.298 ± 0.038 |
J | Quinidine | 8.1 | Base | 0.274 ± 0.020 | 0.218 ± 0.001 | 0.299 ± 0.060 | 0.251 ± 0.026 |
K | Tranylcypromine | 8.2 | Base | 0.630 ± 0.027 | 0.612 ± 0.107 | 0.530 ± 0.051 | 0.490 ± 0.096 |
L | Haloperidol | 8.3 | Base | 0.223 ± 0.032 | 0.161 ± 0.018 | 0.164 ± 0.027 | 0.124 ± 0.014 |
M | Risperidone | 8.3 | Base | 0.276 ± 0.029 | 0.186 ± 0.030 | 0.222 ± 0.051 | 0.163 ± 0.044 |
N | Trimipramine | 8.4 | Base | 0.106 ± 0.016 | 0.054 ± 0.013 | 0.052 ± 0.004 | 0.037 ± 0.016 |
O | Verapamil | 8.7 | Base | 0.233 ± 0.035 | 0.160 ± 0.016 | 0.154 ± 0.022 | 0.137 ± 0.021 |
P | Midazolam | 9.0 | Base | 0.034 ± 0.005 | 0.036 ± 0.004 | 0.041 ± 0.009 | 0.019 ± 0.006 |
Q | Imipramine | 9.4 | Base | 0.220 ± 0.016 | 0.181 ± 0.030 | 0.172 ± 0.043 | 0.105 ± 0.034 |
R | Paroxetine | 9.5 | Base | 0.136 ± 0.011 | 0.099 ± 0.026 | 0.089 ± 0.020 | 0.074 ± 0.006 |
S | Propranolol | 9.6 | Base | 0.315 ± 0.021 | 0.231 ± 0.046 | 0.213 ± 0.015 | 0.216 ± 0.031 |
T | Milnacipran | 9.7 | Base | 0.809 ± 0.048 | 0.837 ± 0.071 | 0.777 ± 0.110 | 0.828 ± 0.024 |
U | Fluoxetine | 10.1 | Base | 0.079 ± 0.015 | 0.056 ± 0.006 | 0.063 ± 0.011 | 0.040 ± 0.013 |
Carbamazepine | Neutral | 0.303 ± 0.021 | 0.291 ± 0.029 | 0.288 ± 0.053 | 0.299 ± 0.023 |