Physicochemical properties of selected cationic drugs
| Cationic Drugs | Molecular Weight | logPappa | fuBb | pKac | Metabolism Enzyme |
|---|---|---|---|---|---|
| Propranolol | 259.34 | 3.10 | 0.69 | 9.45 | CYP2D2 |
| Labetalol | 328.41 | 2.69 | 0.57 | 7.4 | Glucuronosyl transferase |
| Metoprolol | 267.36 | 1.79 | 0.76 | 9.17 | CYP2D2/3A2 |
| Antipyrine | 188.23 | 0.33 | 1.00 | 1.45 | CYP3A2 |
| Atenolol | 266.34 | 0.14 | 0.47 | 9.6 | CYP2D2 |
↵ Log octanol/water partition coefficient at pH 7.4 values (Hung et al., 2001).
↵ Fraction unbound in perfusate acquired with microfiltration method.
↵ Negative logarithm of the ionization constant.