Kinetic parameters derived from two-phase stochastic model fitting for cationic drugs in control and NASH model rat livers (mean ± S.D., n = 6)

Cationic Drugs	PS (ml · min⁻¹ · g liver)		K_v		CL_int (ml · min⁻¹ · g liver)		K_S		K_R
Cationic Drugs	Control	NASH	Control	NASH	Control	NASH	Control	NASH	Control	NASH
Propranolol	37.28 ± 2.43	25.94 ± 2.12^**	10.76 ± 1.40	16.31 ± 1.25^**	7.50 ± 1.26	11.31 ± 1.64^**	13.59 ± 2.04	5.35 ± 1.45^**	1.96 ± 0.85	0.38 ± 0.16^**
Labetalol	16.22 ± 1.46	8.97 ± 1.13^**	6.45 ± 1.13	10.94 ± 1.02^**	3.34 ± 0.69	5.72 ± 1.63^**	6.78 ± 1.45	11.81 ± 2.62^**	1.08 ± 0.27	1.94 ± 0.80^*
Metoprolol	13.43 ± 1.24	7.59 ± 1.40^**	9.64 ± 1.07	11.97 ± 0.76^**	1.13 ± 0.20	1.80 ± 0.56^*	2.27 ± 0.71	1.78 ± 0.38
Antipyrine	10.01 ± 0.90	6.97 ± 0.96^**	2.67 ± 0.22	4.50 ± 0.57^**	0.14 ± 0.04	0.24 ± 0.04^**
Atenolol	5.91 ± 0.67	2.60 ± 0.45^**	9.90 ± 0.92	12.51 ± 1.09^**	0.65 ± 0.18	0.93 ± 0.21^*	11.85 ± 1.59	9.30 ± 2.16