Reference compounds used for identification of metabolites isolated from plasma, urine, and feces after sublingual dosing of unlabeled asenapine followed by a single sublingual dose of [14C]asenapine

Org CodeShort Metabolite NameChemical Name
Org 5222Asenapine(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]-oxepino[4,5-c]pyrrole (2Z)-2-butenedioate (1:1)
Org 30526N-Desmethylasenapinetrans-5-Chloro-2-H-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole maleate
Org 31437Asenapine N-oxidetrans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole 2-oxide
Org 207652-0N-Formylasenapinetrans-5-Chloro-2-formyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole
Org 213772-011-Hydroxyasenapinetrans-5-Chloro-11-hydroxy-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c] pyrrole
Org 213913-111-Hydroxy-N-desmethylasenapinetrans-5-Chloro-11-hydroxy-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole hydrochloride
Org 214025-0Asenapine 11-O-sulfatetrans-5-Chloro-11-sulfooxy-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole
Org 216761-0Asenapine N+-glucuronidetrans-5-Chloro-2(β-d-glucopyranuronosyl)-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrolium
Org 220473-07-Hydroxyasenapinetrans-5-Chloro-7-hydroxy-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole
Org 213979-011-Hydroxy-N-formylasenapinetrans-5-Chloro-2-formyl-11-hydroxy-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole
Org 237498-011-Methoxyasenapinetrans-5-Chloro-2-methyl-11-methoxy-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole
Org 225789-011-Hydroxyasenapine N-oxidetrans-5-Chloro-2,3,3a,12b-tetrahydro-11-hydroxy-2-methyl-1H-dibenzo[2,3:6,7]-oxepino[4,5-c]pyrrole 2-oxide
Org 191475-0N-Desmethylasenapine-N-carbamoylglucuronide1-((3aR,12bR)-Rel-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole-2-carboxylate)-d-glucopyranuronic acid