TABLE 2

Metabolite and ATV concentrations for in vivo samples

Subject Group^{^a}	ATV AUC	M1 AUC	M2 AUC	M1/ATV Ratio^{^b}	M2/ATV Ratio^{^b}	ATV CL/F
	μg · h/ml	ng · h/ml				l per h/kg
1	33.2	2.9	270	0.09	8.1	0.13
1	24.9	2.0	207	0.08	8.3	0.18
1	17.7	2.4	151	0.14	8.6	0.25
1	32.8	3.3	300	0.10	9.2	0.16
1	17.4	2.0	169	0.11	9.8	0.22
Average	25.2	2.5	219	0.10	8.8	0.19
S.D.	7.7	0.6	64	0.02	0.7	0.05
2	9.9	1.7	82	0.18	8.3	0.43
2	18.3	3.9	268	0.21	14.6	0.34
2	16.5	4.9	267	0.29	16.2	0.37
2	10.9	3.1	184	0.28	16.9	0.38
Average	13.9	3.4	200	0.24	14.0	0.38
S.D.	4.1	1.4	88	0.05	3.9	0.04
3	29.3	6.0	431	0.21	14.7	0.19
3	28.1	6.6	481	0.23	17.1	0.16
3	35.9	8.4	639	0.23	17.8	0.21
3	38.6	8.1	700	0.21	18.1	0.13
3	36.5	9.1	683	0.25	18.7	0.15
Average	33.7	7.6	587	0.23	17.3	0.17
S.D.	4.7	1.3	123	0.02	1.6	0.03

↵a Group 1, non-African-American CYP3A5 nonexpressors; group 2, non-African-American CYP3A5 expressors; group 3, African-American CYP3A5 expressors.
↵b For readability, the actual value was 1000-fold lower; the ATV AUC units are micrograms · hour per milliliter and metabolite units are nanograms · hour per milliliter.