Receptor-related parameter estimates obtained from the tracer component of the CERA TIM study in normal and BM-ablated sheep using the physiological model
| Parameter (units) | Definition | Normal (n = 5) | Ablated (n = 5) | p Value | MSE% (n = 10) |
|---|---|---|---|---|---|
| Mean (CV%) | |||||
| ksyn/R0 (1/h) | Initial EPOR normalized synthesis rate constant | 164.3 (31.3) | 71.5 (48.1) | <0.01 | 8.7 |
| kdeg (1/h) | EPOR degradation rate constant | 42.5 (32.4) | 11.7 (57.9) | <0.01 | 8.7 |
| KD (pmol) | CERA/EPOR equilibrium dissociation constant | 88.4 (18.3) | 62.1 (44.8) | >0.05 | 12.3 |
| kint (1/h) | CERA/EPOR internalization rate constant | 2.41 (17.7) | 0.009 (44.9) | <0.01 | 29 |