Summary of the metabolite profile generated after incubation of I-387 with liver microsomes of mouse, rat, dog, monkey, and human
| Compound | Retention Time | [M + H]+ | Fragment Ions |
|---|---|---|---|
| min | |||
| I-387 | 11.3–11.4 | 388 | 192 |
| Demethylation in C ring | |||
| M1 | 10.6 | 375 | 192 |
| M4 | 10.8 | ||
| Reduction of ketone | |||
| M2 | 10.5 | 390.5 | 154, 194, 222 |
| Demethylation in C ring and hydroxylation in A/B ring | |||
| M5 | 9.5 | 390.5 | 208 |
| M6 | 9.7 | ||
| M7 | 11.4 | ||
| Hydroxylation in A/B ring | |||
| M8 | 10 | 404.5 | 208 |
| M3 | 10.2–10.3 | ||
| M9 | 10.6 |