Pharmacokinetic parameters of rivoglitazone after intravenous administration to rats and monkeys
Values represent means ± S.D.
| Species | Dose | AUC0–t | AUC0–inf | CLtot | Vss | t1/2 |
|---|---|---|---|---|---|---|
| mg/kg | μg · h/ml | ml per min/kg | l/kg | h | ||
| Rat | 0.1 (n = 3) | 4.53 ± 0.07 | 4.67 ± 0.07 | 0.329 ± 0.005 | 0.125 ± 0.002 | 4.55 ± 0.04 |
| 0.5 (n = 4) | 22.3 ± 1.0 | 22.9 ± 1.0 | 0.333 ± 0.014 | 0.131 ± 0.006 | 4.84 ± 0.31 | |
| Monkey | 0.0986 (n = 4) | 3.80 ± 1.64 | 5.00 ± 1.21 (n = 3) | 0.312 ± 0.071 (n = 3) | 0.166 ± 0.022 (n = 3) | 6.38 ± 2.10 |
| 0.493 (n = 4) | 21.7 ± 7.6 | 23.5 ± 9.0 | 0.371 ± 0.179 | 0.155 ± 0.024 | 6.21 ± 1.46 | |
| 0.986 (n = 4) | 51.7 ± 18.6 | 57.2 ± 22.0 | 0.310 ± 0.166 | 0.138 ± 0.019 | 6.79 ± 1.74 | |