AUC0–t of rivoglitazone and its metabolites after oral dosing of rivoglitazone (1 mg/kg) to rats and monkeys
Values represent means (n = 4).
| Compound | Rat | Monkey | ||
|---|---|---|---|---|
| AUC0–ta | Ratio of Molar Basis AUC0–t of Rivoglitazone | AUC0–ta | Ratio of Molar Basis AUC0–t of Rivoglitazone | |
| ng · h/ml | % | ng · h/ml | % | |
| Rivoglitazone | 40,500 | 100 | 31,400 | 100 |
| M5 | N.A. | N.A. | 6.53 | 0.02 |
| M6 | 33.9 | 0.08 | 36.7 | 0.11 |
| M7 | 0.356 (n = 3) | 0.00 | 21.0 | 0.06 |
| M9 | N.A. | N.A. | 673 | 1.53 |
| M10 | 9.85 | 0.02 | 27.0 | 0.08 |
| M11 | 11,000 | 23.4 | 200 | 0.64 |
| M12 | 280 | 0.72 | 310 | 1.22 |
| M13 | N.A. | N.A. | 892 | 2.15 |
| M15 | N.A. | N.A. | 12.3 (n = 2) | 0.03 |
| M16 | N.A. | N.A. | 85.4 | 0.28 |
| M17 | 9.59 | 0.02 | 2300 | 7.01 |
| M18 | 11.4 | 0.03 | 7.33 | 0.02 |
| M19 | 3.29 | 0.01 | 76.8 | 0.25 |
| M20 | 2.71 | 0.01 | 16.9 | 0.05 |
N.A., not applicable.
↵ t represents the last quantifiable time for each analyte.