Qualitative metabolite profiles in urine, feces, and bile after oral administration of [14C]rivoglitazone (1 mg/kg) to rats
Values represent means (n = 4).
| Compound | Urine (0–48 h) | Feces (0–48 h) | Bile (0–48 h) | Urine + Feces (0–48 h) | Urine + Bile (0–48 h) |
|---|---|---|---|---|---|
| % of dose | |||||
| Rivoglitazone | N.D. | 23.7 | N.D. | 23.7 | N.D. |
| M1 | N.D. | N.D. | 3.8 | N.D. | 3.8 |
| M2 | 0.7 | N.D. | 2.8 | 0.7 | 3.5 |
| M3 | N.D. | N.D. | 1.3 | N.D. | 1.3 |
| M4 | N.D. | N.D. | 1.5 | N.D. | 1.5 |
| M5 | N.D. | N.D. | 0.6 | N.D. | 0.6 |
| M6 | 3.9 | N.D. | 0.6 | 3.9 | 4.5 |
| M7 | 1.7 | N.D. | N.D. | 1.7 | 1.7 |
| M8 | N.D. | 8.7 | N.D. | 8.7 | N.D. |
| M7, M8, M9 | N.D. | N.D. | 9.2 | N.D. | 9.2 |
| M10 | 1.0 | N.D. | 1.0 | 1.0 | 2.0 |
| M11 | 10.0 | N.D. | 23.0 | 10.0 | 33.0 |
| M12 | N.D. | 25.6 | N.D. | 25.6 | N.D. |
| M13 | N.D. | N.D. | 1.0 | N.D. | 1.0 |
| M19 | N.D. | 3.0 | N.D. | 3.0 | N.D. |
| Unknown metabolites | 3.1 (12 peaks) | 13.8 (>28 peaks) | 2.1 (8 peaks) | 16.9 | 5.2 |
| Total | 20.4 | 74.8 | 46.9 | 95.2 | 67.3 |
N.D., not detected.