Qualitative metabolite profiles in urine and feces after oral administration of [14C]rivoglitazone (1 mg/kg) to monkeys
Values represent means (n = 3 for urine and n = 4 for feces).
| Compound | Urine (0–72 h) | Feces (0–72 h) | Urine + Feces (0–72 h) |
|---|---|---|---|
| % of dose | |||
| Rivoglitazone | 0.3 | 23.5 | 23.8 |
| M2 | 1.2 | N.D. | 1.2 |
| M4 | 2.6 | N.D. | 2.6 |
| M5, M6 | 4.8 | N.D. | 4.8 |
| M7, M15 | 4.1 | N.D. | 4.1 |
| M8 | N.D. | 2.9 | 2.9 |
| M9 | N.D. | 6.6 | 6.6 |
| M10 | 1.3 | N.D. | 1.3 |
| M11, M12 | 8.1 | N.D. | 8.1 |
| M12 | N.D. | 18.0 | 18.0 |
| M13 | 1.4 | N.D. | 1.4 |
| M16 | 3.8 | N.D. | 3.8 |
| M18 | 0.4 | 1.7 | 2.1 |
| M19 | N.D. | 0.8 | 0.8 |
| Unknown metabolites | 7.4 (14 peaks) | 11.0 (>38 peaks) | 18.4 |
| Total | 35.4 | 64.5 | 99.9 |
N.D., not detected.