Pharmacokinetics parameters of luteolin after intravenous administration of 6.5 mg/kg luteolin to vehicle-treated or entacapone-treated rats
Data are expressed as the mean ± S.D. n = 5. Vehicle: 20% hydroxypropyl-β-cyclodextrin (w/v) containing 5% glucose (w/v). Both entacapone and luteolin for intravenous administration were dissolved in this vehicle.
| Parameters | Vehicle + Luteolin | Entacapone + Luteolin |
|---|---|---|
| AUC0–t (μg/ml · h) | 7.60 ± 1.10 | 11.4 ± 2.3** |
| AUC0–∞ (μg/ml · h) | 8.18 ± 0.87 | 12.5 ± 2.5** |
| MRT0–t (h) | 1.41 ± 0.17 | 1.65 ± 0.09* |
| MRT0–∞ (h) | 2.32 ± 0.43 | 2.68 ± 0.31 |
| t1/2 (h) | 3.20 ± 0.70 | 3.31 ± 0.55 |
| CL (l/h/kg) | 0.801 ± 0.076 | 0.537 ± 0.097** |
| V (l/kg) | 3.74 ± 1.10 | 2.57 ± 0.63 |