Metabolic activities of recombinant microsomal enzyme systems toward AR-67
| P450 Enzyme | Phase I Oxidation Activity | UGT Enzyme | Phase II Glucuronidation Activity |
|---|---|---|---|
| peak area/min/pmol P450/1000 | peak area/min/mg protein/1000 | ||
| 1A1 | 11.5 ± 1.2 | 1A1 | 15.7 ± 6.2 |
| 1A2 | 0.2 ± 0.1 | 1A3 | 47.3 ± 16.6 |
| 2C8 | BDL | 1A4 | BDL |
| 2C9*1 | BDL | 1A6 | BDL |
| 2C19 | BDL | 1A7 | 321.7 ± 63.2 |
| 2D6*1 | BDL | 1A8 | 1311.6 ± 295.5 |
| 3A4 | 9.8 ± 0.2 | 1A9 | 5.9 ± 15.0 |
| 3A5 | 36.0 ± 2.1 | 1A10 | BDL |
| Blank | BDL | 2B4 | 0.3 ± 7.5 |
| 2B7 | BDL | ||
| 2B15 | BDL | ||
| 2B17 | BDL | ||
| Blank | BDL |
BDL, beneath detection limits.