Comparison of the chemical shift of protons of oxymetazoline and glutathione conjugate of oxymetazoline (M6)
| Relevant Proton | Chemical Shift in ppm (No. of Integrated Hs) | |
|---|---|---|
| Oxymetazoline | Oxymetazoline Glutathione Conjugate | |
| HA | 1.347 (9 Hs) | 1.317 (9 Hs) |
| HB | 2.107 (3 Hs) | 3.689 (2 Hs) |
| HC | 2.181 (3 Hs) | 2.070 (3 Hs) |
| HD | 3.774 (4 Hs) | N.D.a |
| HE | 3.858 (2 Hs) | N.D. |
| HF | 6.898 (1 H) | 6.918 (1 H) |
↵ N.D., the chemical shifts for protons HD and HE could not be clearly identified in the spectrum because of their overlapping with the glutathione protons between 3 and 4 ppm.