Kinetic parameters for M5 formation in male rat liver microsomes and expressed P450 enzymes
S.E. is shown in parentheses.
| RLM | 1A1 | 1A2 | 3A1 | 3A2 | |
|---|---|---|---|---|---|
| Best model fit | Sigmoidal | Hyperbolic | Sigmoidal | Sigmoidal | Hyperbolic |
| Vmax | 30.6 (1.2) | 145.1 | 25.7 (1.4) | 233.0 (7.1) | 120.8 |
| S50 or Km (μM) | 10.6 (1.1) | 6.0 | 8.2 (0.9) | 8.2 (0.7) | 2.2 |
| Hill coefficient | 1.2 (0.1) | 1.2 (0.1) | 1.3 (0.1) |