TABLE 3

Tissue/PBS (pH 7.4) partition coefficients of corticosteroids in bovine sclera and CRPE

The partition coefficient was calculated as a ratio of drug concentration in tissue to that in PBS (pH 7.4) after incubation for 6 h at 37°C. Three different concentrations (0.4, 2, and 10 μg/ml) were used for estimating the partition coefficient. Data are expressed as the mean ± S.D. for n = 5.

Steroid	Concentration	Sclera/PBS	CRPE/PBS
	μg/ml
Triamcinolone	0.4	4.36 ± 1.30	13.53 ± 2.97
	2	3.00 ± 0.97	10.59 ± 4.07
	10	3.55 ± 1.60	7.12 ± 3.42
Prednisolone	0.4	8.06 ± 2.00	31.27 ± 3.08
	2	4.42 ± 0.12	16.76 ± 1.49
	10	4.75 ± 0.77	10.67 ± 2.61
Dexamethasone	0.4	7.90 ± 2.38	27.90 ± 4.14
	2	5.12 ± 0.29	18.57 ± 2.32
	10	4.90 ± 0.87	11.62 ± 1.83
Triamcinolone acetonide	0.4	7.64 ± 2.09	26.30 ± 4.33
	2	6.22 ± 0.43	19.80 ± 2.53
	10	6.93 ± 0.66	14.60 ± 1.57
Fluocinolone acetonide	0.4	9.12 ± 3.55	24.83 ± 3.68
	2	6.20 ± 0.36	16.30 ± 1.52
	10	6.72 ± 0.42	11.59 ± 1.77
Budesonide	0.4	11.34 ± 2.98	35.75 ± 5.22
	2	9.99 ± 0.43	27.60 ± 2.35
	10	9.96 ± 1.41	19.20 ± 3.20