n | Vmax | Km | Vmax/Km | Ki | ||
---|---|---|---|---|---|---|
ITCZ, nM | CMD, μM | |||||
nmol per min/nmol P450 | μM | μl per min/nmol P450 | ||||
CYP3A4.1 | 5 | 22 (18.6–25.1) | 290 (232–372) | 0.074 ± 0.0094 | 76 (45.1–129) | 370 (285–471) |
CYP3A4.2 | 5 | 6.3 (4.96–7.63) | 220 (177–272) | 0.029 ± 0.0073 | 45 (30.7–65.7) | 360 (334–392) |
CYP3A4.7 | 5 | 38 (24.9–51.5) | 400 (243–663) | 0.090 ± 0.018 | 180* (146–219) | 230* (192–286) |
CYP3A4.16 | 5 | 4.2 (3.77–4.63) | 440 (338–555) | 0.0099 ± 0.0028 | 41 (17.1–99.8) | 1200* (784–1790) |
CYP3A4.18 | 5 | 26 (22.0–29.3) | 140 (83.6–223) | 0.20 ± 0.096 | 82 (51.4–133) | 140* (104–196) |
n, the number of experiments.
↵ P < 0.05 vs. CYP3A4.1.