TABLE 2

Summary of unbound fraction of plasma protein binding and blood-to-plasma concentration ratio

n = 2–3.

Compound	f_u					R_B
Compound	Mouse	Rat	Monkey	Dog	Human	Mouse	Rat	Monkey	Dog	Human
Ketoprofen	0.095	0.011	0.014	0.024	0.004	0.76	1.04	1.24	0.67	1.07
Imipramine	0.063	0.106	0.030	0.053	0.104	1.71	2.13	1.69	1.46	1.67
Lorazepam	0.158	0.090	0.103	0.073	0.057	0.92	1.09	0.87	0.77	1.14
Levofloxacin	0.755	0.826	0.871	0.922	0.784	1.91	2.01	1.12	1.07	1.52
Zidovudine	0.896	0.734	0.707	0.827	0.695	0.77	1.11	0.88	0.88	1.11
Diclofenac	0.005	0.006	0.005	0.003	0.003	0.67	1.57	1.01	1.01	0.71
Furosemide	0.091	0.006	0.022	0.048	0.004	0.96	1.33	1.13	1.46	0.70
Raloxifene	0.006	0.004	0.004	0.003	0.002	1.11	1.36	1.36	0.93	1.05
Gemfibrozil	0.041	0.010	0.007	0.004	0.005	0.68	0.83	0.67	0.64	0.75
Mycophenolic acid	0.028	0.004	0.011	0.003	0.003	0.81	0.94	0.97	0.75	0.69
Indomethacin	0.009	0.004	0.005	0.005	0.100	0.46	0.97	1.06	0.65	0.98
Telmisartan	0.071	0.007	0.008	0.018	0.003	0.54	1.25	1.16	1.18	1.24