TABLE 6

Comparison of f_m,UGT in each animal species

Compound	f_{m, UGT}^{^a}
Compound	Mouse	Rat	Monkey	Dog	Human^{^b}
Ketoprofen	0.010	0.853	0.350	0.163	0.900
Imipramine	ND	0.014	0.040	0.005	0.100
Lorazepam	0.436	0.085	0.530	0.785	0.810
Levofloxacin	0.229	0.644	0.820	0.061	<0.015
Zidovudine	0.034	0.020	0.080	0.134	0.850
Diclofenac	0.261	0.065	0.290	0.522	0.150
Furosemide	0.005	0.052	0.671	0.170	0.140
Raloxifene	0.243	0.214	0.380	0.196	0.900
Gemfibrozil	0.173	0.366	0.350	0.690	0.400
Mycophenolic acid	0.966	0.096	0.540	0.990	0.900
Indomethacin	0.001	0.004	0.940	0.010	0.217
Telmisartan	0.118	0.396	0.470	0.990	NA
Percentage of compounds within
2-fold	30	20	40	40
3-fold	40	40	70	40
4-fold	60	40	70	50

NA, not available; ND, not detected.
↵a Preclinical f_m,UGT values were derived from the recovery of glucuronide excreted in bile and urine (n = 2–3).
↵b Clinical f_m,UGT values were obtained from the literature as follows: ketoprofen, zidovudine, and gemfibrozil (Kilford et al., 2009); imipramine and furosemide (Soars et al., 2002); lorazepam (Greenblatt, 1981); levofloxacin (Fish and Chow, 1997); diclofenac (Stierlin et al., 1979); raloxifene and mycophenolic acid (Cubitt et al., 2009); and indomethacin (Duggan et al., 1972).