Drug | T01: Ivermectin | T02: Spinosad | T03 | |
---|---|---|---|---|
Ivermectin | Spinosad | |||
Dose (mg/kg) | 0.0815 ± 0.00319a | 38.0 ± 7.0 | 0.0562 ± 0.0211a | 40.8 ± 5.2 |
Cmax, obs (ng/ml) | 24.0 ± 6.6 | 1550 ± 356 | 60.1 ± 20.9 | 2100 ± 904 |
(P = 0.0298)b | ||||
Tmax, obs (h) | 5.3 ± 4.0 | 3.3 ± 2.3 | 5.0 ± 4.4 | 5.0 ± 4.4 |
t1/2 (h) | 106 ± 33 | 271 ± 30 | 140 ± 11 | 265 ± 51 |
AUC0–∞ (ng × h/ml) | 934 ± 241 | 55,900 ± 23,900 | 3400 ± 538 | 62,500 ± 15,700 |
(P = 0.0010)b | ||||
CL/F (ml · h−1 · kg−1) | 67.3 ± 15.1 | 571 ± 183 | 17.7 ± 2.5 | 523 ± 141 |
(P = 0.0013)b |
↵a Ivermectin doses were calculated using the density of the most abundant formulation excipient, propylene glycol (density = 1.036 g/ml).
↵b Denotes that a statistical difference (P < 0.10) was observed during coadministration of drugs relative to single drug administration as described under Materials and Methods.