TABLE 1

Description of CYP2C19 variants examined in this study

Variants	cDNA Change	Location	Amino Acid Change	Allele No. or dbSNP Identification No.	Allele Frequency^{^a}
Variants	cDNA Change	Location	Amino Acid Change	Allele No. or dbSNP Identification No.	Whites	Blacks	Asians
CYP2C19.1A	None		None	CYP2C19*1A
CYP2C19.1B	99C>T, 991A>G	Exon7	I331V	CYP2C19*1B	N.R.	N.R.	0.6–0.955 (1,2)
CYP2C19.5B	99C>T, 991A>G, 1297C>T	Exon9	I331V, R433W	CYP2C19*5B	0 (3)	N.R.	0–0.001 (3)
CYP2C19.6	99C>T, 395G>A, 991A>G	Exon3	R132Q, I331V	CYP2C19*6	0–0.003 (4)	N.R.	N.R.
CYP2C19.8	99C>T, 358T>C	Exon3	W120R	CYP2C19*8	0–0.007 (5)	N.R.	N.R.
CYP2C19.9	991A>G	Exon3	R144H, I331V	CYP2C19*9	0–0.0029 (6–8)	0.04–0.06 (6,7)	0 (6,7)
CYP2C19.10	99C>T, 680C>T, 991A>G	Exon5	P227L, I331V	CYP2C19*10	0 (6,8)	0.02 (6)	0 (6)
CYP2C19.11	99C>T, 449G>A, 991A>G	Exon3	R150H, I331V	CYP2C19*11	0–0.03 (6,8)	0 (6)	0 (6)
CYP2C19.13	99C>T, 991A>G, 1228C>T	Exon8	I331V, R410C	CYP2C19*13	0 (6,8)	0.02 (6)	0 (6)
CYP2C19.14	96C>T, 99C>T, 991A>G	Exon1	L17P, I331V	CYP2C19*14	0 (6)	0.02 (6)	0 (6)
CYP2C19.15	55A>C, 99C>T	Exon1	I19L	CYP2C19*15	0 (6)	0.02 (6)	0 (6)
CYP2C19.16	99C>T, 1324C>T	Exon9	R442C	CYP2C19*16	N.R.	N.R.	0–0.017 (9)
CYP2C19.18	99C>T, 986G>A;	Exon7	R329H	CYP2C19*18	N.R.	N.R.	0.002 (1)
CYP2C19.19	99C>T, 151A>G;	Exon1	S51G	CYP2C19*19	N.R.	N.R.	0.002 (1)
E92D	99C>T, 276G>C, 991A>G	Exon2	E92D, I331V	CYP2C19*2B	0.02–0.0047 (6,8)	0 (6)	0 (6)
A161P	99C>T, 481G>C, 991A>G,	Exon3	A161P, I331V	CYP2C19*2C	N.R.	N.R.	0.006 (1)
D360N	99C>T, 991A>G, 1078G>A	Exon7	D360N, I331V	CYP2C19*3B	N.R.	N.R.	0.002–0.02 (1,2)
M74T	221T>C	Exon2	M74T	rs28399505	0 (7)	0 (7)	0.05 (7)
F168L	502T>C	Exon4	F168L	rs28399510	0.02 (7)	0 (7)	0 (7)
E122A	356A>C	Exon3	E122A	rs17885179	0.006 (mixed population in North America) (10)
W212C	636G>T	Exon4	W212C	rs4986893

N.R., not reported.
↵a The allele frequencies are from the following references: 1, Fukushima-Uesaka et al. (2005); 2, Zhou et al. (2009); 3, Ibeanu et al. (1998a); 4, Ibeanu et al. (1998b); 5, Ibeanu et al. (1999); 6, Blaisdell et al. (2002); 7, Solus et al. (2004); 8, Nakamoto et al. (2007); 9, Morita et al. (2004); and 10, http://www.ncbi.nlm.nih.gov/snp/.