CYP2C19 | S-Mephenytoin 4′-Hydroxylation | Omeprazole 5′-Hydroxylation | ||
---|---|---|---|---|
S-Mephenytoin = 25 μM | S-Mephenytoin = 200 μM | Omeprazole = 5 μM | Omeprazole = 100 μM | |
pmol · min−1 · pmol−1 | ||||
CYP2C19.1A | 2.83 ± 0.58 | 5.08 ± 0.24 | 2.75 ± 0.12 | 5.87 ± 0.40 |
CYP2C19.1B | 2.96 ± 0.28 | 5.23 ± 0.43 | 2.73 ± 0.19 | 5.36 ± 0.68 |
CYP2C19.5B | N.D. | N.D. | N.D. | N.D. |
CYP2C19.6 | N.D. | N.D. | N.D. | N.D. |
CYP2C19.8 | N.D. | 0.22 ± 0.05** | N.D. | 0.72 ± 0.08** |
CYP2C19.9 | 1.16 ± 0.14** | 3.32 ± 0.28** | 1.95 ± 0.29 | 5.48 ± 0.87 |
CYP2C19.10 | 0.43 ± 0.10** | 1.48 ± 0.36** | 1.94 ± 0.05 | 5.00 ± 0.54 |
CYP2C19.11 | 2.34 ± 0.21 | 4.82 ± 0.23 | 2.84 ± 0.25 | 6.38 ± 0.74 |
CYP2C19.13 | 2.07 ± 0.42* | 4.26 ± 0.34 | 3.03 ± 1.81 | 8.55 ± 4.06 |
CYP2C19.14 | 2.98 ± 0.40 | 5.16 ± 0.30 | 2.85 ± 0.24 | 8.25 ± 0.73 |
CYP2C19.15 | 2.68 ± 0.30 | 5.60 ± 0.49 | 3.41 ± 0.06 | 7.81 ± 0.25 |
CYP2C19.16 | 0.33 ± 0.20** | 0.57 ± 0.18** | 0.65 ± 0.09** | 1.41 ± 0.12** |
CYP2C19.18 | 1.61 ± 0.39** | 4.89 ± 0.24 | 2.21 ± 0.47 | 4.83 ± 0.52 |
CYP2C19.19 | 2.09 ± 0.17* | 6.13 ± 0.58 | 2.82 ± 0.31 | 8.65 ± 0.20 |
E92D | 1.97 ± 0.20* | 3.57 ± 0.32** | 2.95 ± 0.25 | 7.02 ± 0.06 |
A161P | 0.23 ± 0.07** | 0.75 ± 0.20** | 0.65 ± 0.10** | 1.39 ± 0.15** |
D360N | 0.94 ± 0.22** | 1.95 ± 0.10** | 1.81 ± 0.34 | 4.10 ± 0.43 |
M74T | 1.13 ± 0.22** | 3.56 ± 1.27** | 2.24 ± 0.05 | 4.27 ± 0.03 |
F168L | 2.54 ± 0.22 | 4.91 ± 0.48 | 3.08 ± 0.05 | 5.48 ± 0.91 |
E122A | 2.09 ± 0.41* | 4.40 ± 0.43 | 1.580 ± 0.17 | 4.71 ± 0.31 |
W212C | 0.45 ± 0.20** | 1.43 ± 0.12** | 0.58 ± 0.21** | 1.78 ± 0.27** |